The Effect of Intravenous Lidocaine or Ketamine on Interleukin-6 Levels in Patients Undergoing Colorectal Surgery for Cancer: A Randomized Controlled Trial
Patients undergoing open colorectal surgery were randomly divided into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta). For the IV-Lido group, patients received a loading dose of Lidocaine than a continuous infusion over twenty-four hours. For the IV-Keta goup, patients received a loading dose of Ketamine than a continuous injection of Ketamine over twenty-four hours. Plasma concentrations of Interleukin-6(IL-6) were measured preoperatively before anesthetic induction and at twenty-four hour post operatively.
• Patients aged 18 or older.
• American society of anesthesiologists' (ASA) physical status of I-III.
• Elective open colorectal surgery.
⁃ NON INCLUSION CRITERIA:
• Patients with contraindications to lidocaine or ketamine.
• Corticosteroid therapy within the last 6 months.
• History of immunosuppressive therapy.
• History of surgery in the last 3 months.
• Personal medical history of inflammatory bowel disease.
• Personal medical history of cardiac arrythmias or conduction disorders.
• Alcohol or drug abuse.
• Chronic use of opioids or benzodiazepines.